生命科学学院 生命科学学院 中国科学院大学生命科学学院 中国科学院大学生命科学学院

环境与健康课题组

  • 发布于 2016-10-01
  • 1388

       环境与健康课题组2004年成立,主要应用生物化学、分子生物学、细胞生物学、实验动物学、生物物理学、核技术等交叉学科从事环境与健康、生命科学方面的基础应用研究工作。近年来承担国家科技部、国家环保部、国家自然科学基金委、中国科学院的科研项目10余项,在Toxicology in Vitro、Cell Biology and Toxicology、Biophysical Journal、 Journal of Inorganic Biochemistry、Journal of Biological Inorganic Chemistry、Journal of Diabetes Research、Biochemical and Biophysical Research Communications、Journal of Nanoscience and Nanotechnology及中国科学、生态毒理学报等期刊上发表学术论文20余篇,已培养研究生20余名。

研究方向:

  1. 环境污染物的生物学效应及毒性作用机制研究,包括大气可吸入颗粒物的理化性质表征和组成成分源解析;
  2. 典型城市大气污染与人群健康的风险评价研究;
  3. 暴露诱发胰岛素抵抗的分子作用机制。

课题组负责人:丁文军 教授

课题组成员:张芳副教授,张薇讲师

博士生:万冲,韩睿,张良,刘芳,黄莹,冯玮

硕士生:张璐瑶,关龙飞,徐进霞,刘珊,刘立民,田国雄

代表性研究成果(近五年发表文章)

  1. Deng XB, et al. Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells. Apoptosis, 2014, 19, 1099-1112.
  2. Wang JT, et al. ZnO nanoparticles-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes. Nanoscale Res Lett, 2014, 9, 117-129.
  3. Xie MX, et al. Effects of vanadium (III, IV, V)-chlorodipicolinate on glycolysis and antioxidant status in the liver of STZ-induced diabetic rats. Journal of Inorganic Biochemistry, 2014, 136, 47-56.
  4. Liu F, et al. Effect of VIVO(dipic-Cl)(H2O)2 on lipid metabolism disorders in the liver of STZ-induced diabetic rats. Journal of Diabetes Research, 2013, doi:10.1155/2013/956737.
  5. Deng X, et al. PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells. Toxicology in Vitro, 2013, 27, 1762-1770.
  6. Deng X, et al. PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells. Cell Biology and Toxicology, 2013, 29, 143-157. 
  7. Yi S, et al. Water-Insoluble Fraction of airborne particulate matter (PM10) induces oxidative stress in human lung epithelial A549 cells. Environmental Toxicology. 2012. doi: 10.1002/tox.21750.
  8. Wei H, et al. Oxidative-stress is induced in human EA.hy926 endothelial cells exposed to fractions of urban fine particles. Human and Experimental Toxicology, 2011, 30, 579-590.